This paper presents a numerical study of damage behavior of asphalt mixtures by using a three-dimensional (3D) micro-frame element network (MFEN) model and damage mechanics principles. Asphalt mixtures are composed of aggregates, mastic cement and air voids. The load carrying behavior is strongly related to the local microstructural load transfer between neighboring aggregate particles. The 3D finite element scheme used a network of special frame elements. Each element stiffness matrix was developed based on an approximate elasticity solution of the stress-strain field in a cementation layer between neighboring particle pairs. Numerical simulation of this micro-mechanical behavior was accomplished by using ABAQUS UEL subroutine that incorporated the mechanical load-carrying response between aggregates. Continuum damage mechanics was then incorporated within each mastic micro-frame element, leading to the construction of a micro-damage model capable of predicting typical global inelastic behavior found in asphalt materials. The Damage behavior simulation was conducted by using the Riks method (Crisfield 1980; 1986). Model simulation results indicate that the MFEN model is capable of predicting the damage behavior under the mechanical loading.